Sugi Predict

Sugi Predict / Compounds / SCHEMBL20510985

SCHEMBL20510985

SCHEMBL20510985

Cc1cccc(NC(=O)c2ccc(OCc3c(C)noc3C)cc2C#N)c1C

nearest known ligand 0.62

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.62
▸ SMN1; SMN2 Q16637 2/20 0.62
▸ MAPT P10636 2/20 0.62
▸ HPGD P15428 1/20 0.62
▸ TSHR P16473 3/20 0.56
▸ ALOX15 P16050 2/20 0.56
▸ HSD17B10 Q99714 1/20 0.55
▸ AKR1C3 P42330 7/20 0.52
▸ ALDH1A1 P00352 4/20 0.52
▸ RAC1 P63000 1/20 0.48
▸ ATM Q13315 1/20 0.48
▸ NPSR1 Q6W5P4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25680297 0.89 LMNA (0.66) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL20510980 0.88 LMNA (0.65) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL20511432 0.86 LMNA (0.63) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL25680341 0.85 AKR1C3 (0.64) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL25680284 0.82 LMNA (0.70) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL20511439 0.81 LMNA (0.64) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL25680353 0.80 LMNA (0.62) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL25680337 0.80 AKR1C3 (0.61) LMNASMN1; SMN2MAPTHPGDTSHR
SCHEMBL20510991 0.78 MEN1 (0.56) LMNASMN1; SMN2MAPTTSHRHSD17B10
SCHEMBL20511038 0.78 LMNA (0.67) LMNASMN1; SMN2MAPTHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12486258-B2 Compounds and methods for regulating insulin secretion THE BROAD INSTITUTE, INC. (US) 2025-12-02 — — US disclosed
US-20230142508-A1 COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION THE BROAD INSTITUTE, INC. (US) 2023-05-11 — — US disclosed
US-20230142508-A1 COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION THE BROAD INSTITUTE, INC. (US) 2023-05-11 — — US disclosed
US-20230142508-A1 COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION THE BROAD INSTITUTE, INC. (US) 2023-05-11 — — US disclosed
US-11555031-B2 Compounds and methods for regulating insulin secretion THE BROAD INSTITUTE, INC. (US) 2023-01-17 — — US disclosed
EP-3601326-A1 COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION The Broad Institute, Inc. (US) 2020-02-05 — — EP disclosed
WO-2018175324-A1 COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION THE BROAD INSTITUTE, INC. (US) 2018-09-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230142508-A1 COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION IAPP, GPR119, PNLIP LMNA 4022/4885SMN1; SMN2 4513/4885MAPT 4653/4885
US-11555031-B2 Compounds and methods for regulating insulin secretion IAPP, GPR119, INSR LMNA 3885/4885SMN1; SMN2 4326/4885MAPT 4534/4885
US-12486258-B2 Compounds and methods for regulating insulin secretion IAPP, GPR119, PNLIP LMNA 4022/4885SMN1; SMN2 4513/4885MAPT 4653/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.