Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18062216 | 0.81 | PIK3CA (0.47) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL20511207 | 0.79 | DCTPP1 (0.52) | NFKB1LMNAP2RX7 | |
| SCHEMBL12963745 | 0.75 | CA12 (0.58) | NPC1RAB9ACA12CA1CA2 | |
| SCHEMBL3789793 | 0.73 | P2RX7 (0.47) | MAPTKMT2AGAANFKB1LMNA | |
| SCHEMBL8973681 | 0.72 | NPC1 (0.56) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL14504152 | 0.72 | LMNA (0.53) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL15476680 | 0.72 | KDM4E (0.53) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL11046759 | 0.71 | HDAC1 (0.47) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL1872934 | 0.70 | KDM4E (0.51) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL3788149 | 0.70 | CD38 (0.46) | NFKB1LMNAP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146779-A1 | mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-07-16 | — | — | WO | disclosed |
| WO-2018175958-A1 | THIOREDOXIN MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-27 | — | — | WO | disclosed |