Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2811770 | 0.86 | CTDSP1 (0.35) | CTDSP1ALDH1A1POLBTXNRD1HTT | |
| SCHEMBL2811773 | 0.86 | CTDSP1 (0.35) | CTDSP1ALDH1A1POLBTXNRD1HTT | |
| SCHEMBL185629 | 0.81 | POLB (0.36) | CTDSP1ALDH1A1POLBHPGDGAA | |
| SCHEMBL185869 | 0.80 | ALDH1A1 (0.35) | CTDSP1ALDH1A1POLBHTTMAPT | |
| SCHEMBL185723 | 0.80 | KCNH2 (0.41) | ALDH1A1POLBHTTMAPTGAA | |
| SCHEMBL185812 | 0.80 | POLB (0.34) | CTDSP1POLBHTTSMN1; SMN2 | |
| SCHEMBL186038 | 0.79 | NAMPT (0.40) | GAA | |
| SCHEMBL186396 | 0.79 | HPGD (0.40) | POLBMAPTHPGDSMN1; SMN2 | |
| SCHEMBL186112 | 0.79 | HDAC1 (0.39) | ALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL185726 | 0.79 | GAA (0.42) | ALDH1A1POLBMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |