Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.37 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185726 | 0.88 | GAA (0.42) | LMNAPOLBCNR2ATMMAPT | |
| SCHEMBL185723 | 0.87 | KCNH2 (0.41) | KDM4ESMN1; SMN2POLBCNR2MAPT | |
| SCHEMBL2806528 | 0.86 | HPGD (0.41) | HPGDTP53GLALMNAKDM4E | |
| SCHEMBL185326 | 0.85 | KMT2A (0.41) | HPGDLMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL185869 | 0.84 | ALDH1A1 (0.35) | HPGDLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL185629 | 0.83 | POLB (0.36) | HPGDLMNAKDM4ESMN1; SMN2P2RX7 | |
| SCHEMBL186112 | 0.83 | HDAC1 (0.39) | POLBMAPT | |
| SCHEMBL186209 | 0.82 | POLB (0.34) | HPGDLMNAKDM4ESMN1; SMN2POLB | |
| SCHEMBL185812 | 0.80 | POLB (0.34) | SMN1; SMN2POLB | |
| SCHEMBL185692 | 0.80 | LMNA (0.39) | LMNASMN1; SMN2P2RX7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |