Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | MAX | P61244 | 1/20 | 0.33 |
| ▸ | CBR1 | P16152 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186112 | 0.94 | HDAC1 (0.39) | ALDH1A1POLBMT-CO2RAB9ANPC1 | |
| SCHEMBL185723 | 0.90 | KCNH2 (0.41) | ALDH1A1POLBSMN1; SMN2KMT2AMAPT | |
| SCHEMBL185726 | 0.87 | GAA (0.42) | ALDH1A1POLBRAB9ANPC1LMNA | |
| SCHEMBL185326 | 0.87 | KMT2A (0.41) | ALDH1A1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL2810328 | 0.85 | BDKRB1 (0.37) | ALDH1A1POLBMT-CO2RAB9ANPC1 | |
| SCHEMBL186396 | 0.84 | HPGD (0.40) | POLBSMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL185629 | 0.83 | POLB (0.36) | ALDH1A1POLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL185812 | 0.82 | POLB (0.34) | POLBSMN1; SMN2PTK2HTTCTDSP1 | |
| SCHEMBL185692 | 0.81 | LMNA (0.39) | ALDH1A1POLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL186209 | 0.80 | POLB (0.34) | ALDH1A1POLBSMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |