Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186105 | 0.88 | RAB9A (0.33) | POLBITGA4EPHX2SMN1; SMN2CTDSP1 | |
| SCHEMBL186209 | 0.88 | POLB (0.34) | POLBITGA4EPHX2SMN1; SMN2CTDSP1 | |
| SCHEMBL185988 | 0.87 | P2RX7 (0.33) | POLBSCN9ACTDSP1HTTRECQL | |
| SCHEMBL13128461 | 0.85 | CTDSP1 (0.36) | POLBKCNH2SCN5ASCN9AADAMTS4 | |
| SCHEMBL13159669 | 0.84 | EPHX2 (0.42) | POLBKCNH2SCN5ASCN9AEPHX2 | |
| SCHEMBL13159831 | 0.84 | EPHX2 (0.42) | POLBKCNH2SCN5ASCN9AEPHX2 | |
| SCHEMBL185629 | 0.82 | POLB (0.36) | POLBEPHX2SMN1; SMN2CTDSP1 | |
| SCHEMBL185869 | 0.82 | ALDH1A1 (0.35) | POLBSMN1; SMN2CTDSP1HTTPTK2 | |
| SCHEMBL185726 | 0.80 | GAA (0.42) | POLBEPHX2MAPK14PTK2 | |
| SCHEMBL185692 | 0.80 | LMNA (0.39) | POLBEPHX2SMN1; SMN2PTK2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |