Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 4/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959821 | 0.89 | NPC1 (0.36) | POLBTSHRSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1958741 | 0.84 | RECQL (0.35) | HTTPOLBTSHRSMN1; SMN2LMNA | |
| SCHEMBL27889611 | 0.83 | CASP3 (0.34) | LMNARECQLBRD4ALDH1A1 | |
| SCHEMBL1963113 | 0.81 | RECQL (0.43) | HTTPOLBTSHRSMN1; SMN2LMNA | |
| SCHEMBL1961925 | 0.81 | FKBP1A (0.36) | HTTPOLBSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1961549 | 0.80 | IDO1 (0.36) | HTTPOLBSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1962022 | 0.79 | RORC (0.42) | — | |
| SCHEMBL1962077 | 0.76 | PDE5A (0.38) | RECQLPDE5APDE4APDE4BPDE4C | |
| SCHEMBL1963563 | 0.76 | RECQL (0.36) | RECQLPDE5APDE4APDE4BPDE4C | |
| SCHEMBL1962683 | 0.75 | ALDH1A1 (0.39) | HTTTSHRSMN1; SMN2LMNABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |