SCHEMBL20522355

SCHEMBL20522355

CC(C)Oc1ccc(-c2ccccc2NCc2ccc3[nH]cnc3c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 3/20 0.38
KDM4C Q9H3R0 1/20 0.36
PRMT3 O60678 1/20 0.35
CARM1 Q86X55 1/20 0.35
PRMT6 Q96LA8 1/20 0.35
PRMT1 Q99873 1/20 0.35
PRMT8 Q9NR22 1/20 0.35
QPCT Q16769 3/20 0.35
ACP1 P24666 1/20 0.35
USP1 O94782 1/20 0.34
WDR48 Q8TAF3 1/20 0.34
BTK Q06187 1/20 0.34
BDKRB1 P46663 1/20 0.33
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
AGTR1 P30556 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29550390 1.00 KDR (0.38) KDRKDM4CPRMT3CARM1PRMT6
SCHEMBL29550590 0.89 ACP1 (0.46) KDRQPCTACP1USP1WDR48
SCHEMBL22712388 0.89 ACP1 (0.46) KDRQPCTACP1USP1WDR48
SCHEMBL20522367 0.86 QPCTL (0.45) KDRKDM4CQPCTACP1BTK
SCHEMBL29551444 0.86 QPCTL (0.45) KDRKDM4CQPCTACP1BTK
SCHEMBL20522272 0.86 QPCT (0.41) KDRQPCTNPC1MAPTRAB9A
SCHEMBL29550890 0.86 QPCT (0.41) KDRQPCTNPC1MAPTRAB9A
SCHEMBL20522432 0.83 QPCT (0.47) KDRQPCTUSP1WDR48ALDH1A1
SCHEMBL29550580 0.83 QPCT (0.47) KDRQPCTUSP1WDR48ALDH1A1
SCHEMBL20522441 0.81 ALDH1A1 (0.38) KDRQPCTUSP1WDR48BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN claimed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US claimed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP claimed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO claimed
US-20260001873-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2026-01-01 US disclosed
US-12384772-B2 Inhibitors VIVORYON THERAPEUTICS N.V. (DE) 2025-08-12 US disclosed
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN disclosed
US-20220274977-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2022-09-01 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-11339152-B2 Inhibitors VIVORYON THERAPEUTICS N.V. 2022-05-24 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
US-20200377493-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2020-12-03 US disclosed
EP-3601269-A1 NOVEL INHIBITORS Probiodrug AG (DE) 2020-02-05 EP disclosed
WO-2018178384-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2018-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001873-A1 NOVEL INHIBITORS GLS, GLS2, SULT1E1 KDR 2611/4885KDM4C 2946/4885PRMT3 374/4885
US-20200377493-A1 NOVEL INHIBITORS GLUL, GLS, QPCT KDR 2432/4885KDM4C 1555/4885PRMT3 1125/4885
US-11339152-B2 Inhibitors GLUL, QPCT, GLS KDR 2483/4885KDM4C 1683/4885PRMT3 920/4885
US-12384772-B2 Inhibitors GLS, QPCT, GLS2 KDR 2197/4885KDM4C 3018/4885PRMT3 1092/4885
US-20220274977-A1 NOVEL INHIBITORS GLUL, GLS, QPCT KDR 2829/4885KDM4C 1525/4885PRMT3 1080/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.