Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.56 |
| ▸ | QDPR | P09417 | 2/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345819 | 0.91 | PDE4B (0.56) | PDE4BQDPRPDE4APDE4CPDE4D | |
| SCHEMBL3639005 | 0.83 | QDPR (0.50) | PDE4BQDPRPDE4APDE4CPDE4D | |
| SCHEMBL30376364 | 0.83 | LMNA (0.49) | PDE4BCHRM4PDE4DCHRM2CHRM1 | |
| SCHEMBL13362111 | 0.82 | QDPR (0.55) | PDE4BQDPRPDE4APDE4CPDE4D | |
| SCHEMBL22659030 | 0.80 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL25260521 | 0.80 | MAPT (0.49) | HTR4CHRM4CHRM5ADRA2CCHRM3 | |
| SCHEMBL2227613 | 0.80 | QDPR (0.59) | PDE4BQDPRPDE4APDE4CPDE4D | |
| SCHEMBL3311407 | 0.80 | QDPR (0.74) | PDE4BQDPRPDE4APDE4CPDE4D | |
| SCHEMBL520443 | 0.80 | QDPR (0.53) | PDE4BQDPR | |
| SCHEMBL310046 | 0.80 | PDE4B (0.62) | PDE4BQDPRPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600327-A1 | HETEROCYCLIC COMPOUND | Cardurion Pharmaceuticals, LLC (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183112-A1 | HETEROCYCLIC COMPOUND | CARDURION PHARMACEUTICALS, LLC (US) | 2018-10-04 | — | — | WO | disclosed |