Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.56 |
| ▸ | QDPR | P09417 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20522882 | 0.91 | PDE4B (0.56) | PDE4BQDPRPDE4APDE4CPDE4D | |
| SCHEMBL30376364 | 0.83 | LMNA (0.49) | PDE4BPDE4DCHRM2CHRM1POLB | |
| SCHEMBL3317065 | 0.80 | PDE4B (0.62) | PDE4BQDPRPDE4APDE4CPDE4D | |
| SCHEMBL22659030 | 0.78 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL29742014 | 0.78 | TRPC6 (0.50) | PDE4BTRPC6CHRM2CHRM1POLB | |
| SCHEMBL8922008 | 0.78 | CHRM4 (0.59) | CHRM2CHRM1POLBLMNASMN1; SMN2 | |
| SCHEMBL21273836 | 0.77 | TRPC6 (0.66) | TRPC6 | |
| SCHEMBL9172873 | 0.77 | CHRM4 (0.47) | PDE4BCHRM2CHRM1POLBLMNA | |
| SCHEMBL4969308 | 0.76 | LMNA (0.46) | PDE4BCHRM2CHRM1POLBLMNA | |
| SCHEMBL2025839 | 0.76 | PDE4B (0.53) | PDE4BPDE4DCHRM2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |