Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23135435 | 0.79 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAMMP1MMP2 | |
| SCHEMBL11525938 | 0.78 | EPHX1 (0.48) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KMT2A | |
| SCHEMBL27564590 | 0.78 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2LMNAMMP1MMP2 | |
| SCHEMBL10616925 | 0.78 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2LMNAMMP1MMP2 | |
| SCHEMBL28702044 | 0.77 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNAMMP1MMP2 | |
| SCHEMBL1790733 | 0.77 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNAMMP1MMP2 | |
| SCHEMBL187996 | 0.76 | ALDH1A1 (0.61) | ALDH1A1LMNAL3MBTL1KMT2ATDP1 | |
| SCHEMBL9186019 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2L3MBTL1KMT2AMEN1 | |
| SCHEMBL1790735 | 0.75 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2LMNAMMP1MMP2 | |
| SCHEMBL2266698 | 0.74 | MCL1 (0.61) | ALDH1A1SMN1; SMN2LMNAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11633415-B2 | Compounds and methods useful for treating or preventing cancers | THE BROAD INSTITUTE, INC. (US) | 2023-04-25 | — | — | US | disclosed |
| US-20220096513-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS | THE BROAD INSTITUTE, INC. (US) | 2022-03-31 | — | — | US | disclosed |
| WO-2018183936-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS | THE BROAD INSTITUTE, INC. (US) | 2018-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096513-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS | CSNK1A1, CSNK2A1, CSNK2A3 | ALDH1A1 626/4885SMN1; SMN2 1105/4885LMNA 1021/4885 |
| US-11633415-B2 | Compounds and methods useful for treating or preventing cancers | CSNK1A1, CSNK2A1, CSNK2A3 | ALDH1A1 626/4885SMN1; SMN2 1105/4885LMNA 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.