Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20524606 | 0.82 | OPRK1 (0.41) | OPRK1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL22712188 | 0.81 | KIT (0.48) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL30323222 | 0.81 | KIT (0.48) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL27741477 | 0.79 | OPRK1 (0.39) | OPRK1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL3434342 | 0.79 | MEN1 (0.40) | OPRK1MEN1KMT2ALMNATP53 | |
| SCHEMBL13106057 | 0.78 | MDM2 (0.44) | OPRK1LMNATP53 | |
| SCHEMBL20524637 | 0.78 | ALDH1A1 (0.49) | OPRK1LMNAMAPTALDH1A1 | |
| SCHEMBL27848265 | 0.74 | ALDH1A1 (0.47) | SMOLMNATP53MAPTALDH1A1 | |
| SCHEMBL16178191 | 0.73 | SMO (0.43) | SMOMEN1KMT2AKDM4ELMNA | |
| SCHEMBL27741480 | 0.73 | SMN1; SMN2 (0.46) | MEN1KMT2ALMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183145-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | WO | disclosed |