Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30323135 | 0.83 | MAPT (0.53) | ALDH1A1MAPK1HTTPOLBOPRK1 | |
| SCHEMBL22712080 | 0.83 | MAPT (0.53) | ALDH1A1MAPK1HTTPOLBOPRK1 | |
| SCHEMBL29274197 | 0.81 | SMN1; SMN2 (0.48) | ALDH1A1MAPK1HTTPOLBLMNA | |
| SCHEMBL20524655 | 0.81 | OPRK1 (0.44) | ALDH1A1MAPK1HTTOPRK1GRM5 | |
| SCHEMBL3435982 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MAPK1HTTPOLBOPRK1 | |
| SCHEMBL4606448 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPK1HTTOPRK1LMNA | |
| SCHEMBL20524610 | 0.78 | SMO (0.38) | ALDH1A1OPRK1LMNAMAPT | |
| SCHEMBL3435641 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MAPK1HTTPOLBOPRK1 | |
| SCHEMBL16178366 | 0.76 | ALDH1A1 (0.66) | ALDH1A1MAPK1HTTLMNASMN1; SMN2 | |
| SCHEMBL6949066 | 0.76 | MAPK1 (0.49) | ALDH1A1MAPK1HTTPOLBGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183145-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | WO | disclosed |