Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525349 | 0.87 | SCN9A (0.46) | JAK1KDM4EDRD4JAK3JAK2 | |
| SCHEMBL20525360 | 0.86 | PARP1 (0.39) | DRD2 | |
| SCHEMBL20525552 | 0.86 | DRD2 (0.36) | SYKDRD2 | |
| SCHEMBL20525428 | 0.86 | KDM4E (0.47) | JAK1KDM4EALDH1A1DRD4KLKB1 | |
| SCHEMBL18109017 | 0.85 | LMNA (0.50) | FAAHKDM4EALDH1A1MAPTDRD4 | |
| SCHEMBL20525429 | 0.85 | CHUK (0.39) | JAK2TYK2SYKDRD2 | |
| SCHEMBL20525337 | 0.84 | FGFR1 (0.34) | SYKDRD2 | |
| SCHEMBL16804168 | 0.84 | HDAC1 (0.50) | FAAHKDM4EALDH1A1MAPTDRD4 | |
| SCHEMBL20525467 | 0.83 | FGFR1 (0.34) | SYKDRD2 | |
| SCHEMBL20525475 | 0.83 | JAK1 (0.47) | JAK1FAAHKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080125-B1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-10-10 | — | — | EP | disclosed |