Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 10/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 2/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379021 | 0.86 | MET (0.77) | METPDGFRAKITKDRPDGFRB | |
| SCHEMBL20525528 | 0.85 | AXL (0.46) | METPDGFRAKDRAXLMEN1 | |
| SCHEMBL20525801 | 0.82 | POLB (0.52) | METAXLRAB9ANPC1ALDH1A1 | |
| SCHEMBL20525758 | 0.81 | HTT (0.49) | PDGFRAKITPDGFRBMEN1KMT2A | |
| SCHEMBL20525750 | 0.79 | KDR (0.47) | METPDGFRAKDRPDGFRBAXL | |
| SCHEMBL20525674 | 0.79 | AXL (0.53) | METPDGFRAKITKDRPDGFRB | |
| SCHEMBL1875882 | 0.78 | MET (0.77) | METPDGFRAKITKDRPDGFRB | |
| SCHEMBL1876150 | 0.78 | MET (0.81) | METPDGFRAKITKDRPDGFRB | |
| SCHEMBL20525766 | 0.78 | ALDH1A1 (0.49) | METPDGFRAKDRPDGFRBAXL | |
| SCHEMBL20525870 | 0.77 | AXL (0.42) | PDGFRAKDRAXLRORCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |