SCHEMBL20525830

SCHEMBL20525830

COc1ccc2c(Oc3ccc(N4CCN(C(=O)Cc5ccccc5)C4=O)cc3F)ccnc2c1OC

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.52
KDR P35968 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL371551 0.87 MET (0.69) METKDR
SCHEMBL20525677 0.86 MET (0.46) METKDR
SCHEMBL15404759 0.80 MET (0.43) METKDR
SCHEMBL20525618 0.78 MET (0.43) METKDR
SCHEMBL15404611 0.77 CYP3A4 (0.46) METKDR
SCHEMBL20525637 0.77 LMNA (0.44) MET
SCHEMBL15404803 0.77 MET (0.42) METKDR
SCHEMBL20525560 0.76 LMNA (0.44) MET
SCHEMBL15404825 0.75 MET (0.41) METKDR
SCHEMBL15405168 0.75 MET (0.41) METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2101759-B1 METHODS OF USING MEK INHIBITORS EXELIXIS INC (US) 2018-10-10 EP claimed