Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20526533 | 0.78 | HRH4 (0.50) | HRH4 | |
| SCHEMBL20526493 | 0.76 | KDM4E (0.63) | HTTRAB9AUSP2MEN1KMT2A | |
| SCHEMBL20526514 | 0.76 | HRH4 (0.53) | HRH4 | |
| SCHEMBL14419475 | 0.75 | ALDH1A1 (0.66) | HTTLMNARAB9AUSP2MEN1 | |
| SCHEMBL20526579 | 0.75 | ALDH1A1 (0.58) | HTTLMNAHRH4MEN1KMT2A | |
| SCHEMBL20526498 | 0.75 | SLC6A2 (0.43) | HTTLMNAHRH4KDM4EALDH1A1 | |
| SCHEMBL1746018 | 0.74 | RAB9A (0.61) | HTTLMNARAB9AUSP2KDM4E | |
| SCHEMBL4894531 | 0.72 | RAB9A (0.63) | HTTRAB9AUSP2KDM4EPOLB | |
| SCHEMBL20526574 | 0.71 | G6PD (0.51) | HRH4 | |
| SCHEMBL9796209 | 0.71 | ALDH1A1 (0.67) | HTTLMNARAB9AUSP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10172856-B2 | 2,4-diaminopyrimidine derivatives as histamine H4 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-08 | — | — | US | disclosed |
| WO-2018187652-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS HISTAMINE H4 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-10-11 | — | — | WO | disclosed |
| US-20180289706-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS HISTAMINE H4 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10172856-B2 | 2,4-diaminopyrimidine derivatives as histamine H4 modulators | HRH4, HRH3, HRH2 | HTT 178/4885LMNA 4837/4885RAB9A 2872/4885 |
| US-20180289706-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS HISTAMINE H4 MODULATORS | HRH4, HRH3, HRH2 | HTT 178/4885LMNA 4837/4885RAB9A 2872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.