Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 7/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740232 | 0.83 | RAB9A (0.68) | MEN1CYP1A2KMT2ARAB9APOLB | |
| SCHEMBL30791436 | 0.83 | CYP1A2 (0.55) | MEN1CYP1A2KMT2ARAB9APOLB | |
| SCHEMBL21669286 | 0.76 | MEN1 (0.61) | MEN1CYP1A2KMT2ARAB9APOLB | |
| SCHEMBL10824289 | 0.75 | MEN1 (0.64) | MEN1CYP1A2KMT2ARAB9APOLB | |
| SCHEMBL28770509 | 0.74 | MLKL (0.38) | MEN1KMT2AHTTHPGDALDH1A1 | |
| SCHEMBL29358626 | 0.74 | CYP1A2 (1.00) | MEN1CYP1A2KMT2ARAB9APOLB | |
| SCHEMBL612643 | 0.74 | CYP1A2 (1.00) | MEN1CYP1A2KMT2ARAB9APOLB | |
| SCHEMBL31000402 | 0.74 | ALDH1A1 (0.54) | MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL29270346 | 0.74 | ALDH1A1 (0.54) | MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL2267066 | 0.73 | CYP1A2 (0.67) | MEN1CYP1A2KMT2ARAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3606921-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. | Inventiva (FR) | 2020-02-12 | — | — | EP | disclosed |
| WO-2018185266-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. | INVENTIVA (FR) | 2018-10-11 | — | — | WO | disclosed |