SCHEMBL20529318

SCHEMBL20529318

N#Cc1ccc(SCC(=O)S)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.47
MAOA P21397 8/20 0.47
MAPK1 P28482 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HSD17B10 Q99714 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
HTT P42858 1/20 0.45
GSK3B P49841 2/20 0.42
CA2 P00918 3/20 0.41
CA1 P00915 2/20 0.41
CA12 O43570 1/20 0.39
CA3 P07451 1/20 0.39
CA6 P23280 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
KDM4E B2RXH2 1/20 0.39
CYP1A2 P05177 1/20 0.39
GLA P06280 1/20 0.39
CYP3A4 P08684 1/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11606889 0.83 HTT (0.59) MAOBMAOAMAPK1SMN1; SMN2HSD17B10
SCHEMBL941215 0.77 PKM (0.47) MAOBMAOAMAPK1SMN1; SMN2HSD17B10
SCHEMBL20529319 0.76 MAOB (0.53) MAOBMAOAMAPK1SMN1; SMN2HSD17B10
SCHEMBL3838084 0.75 ALDH1A1 (0.49) MAOBMAOASMN1; SMN2HSD17B10L3MBTL1
SCHEMBL3074559 0.74 FFAR1 (0.68) MAPK1SMN1; SMN2HSD17B10L3MBTL1HTT
SCHEMBL1535173 0.74 MAOA (0.56) MAOBMAOAMAPK1HSD17B10L3MBTL1
SCHEMBL3840252 0.73 MAOB (0.57) MAOBMAOAMAPK1SMN1; SMN2HSD17B10
SCHEMBL6785504 0.73 DNTT (0.43) MAOBMAOAMAPK1SMN1; SMN2HSD17B10
SCHEMBL10821188 0.71 MAOB (0.52) MAOBMAOAHTTGSK3BCA2
SCHEMBL10718749 0.71 CTBP2 (0.56) HTTGSK3BCA2CA1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018185675-A1 SUBSTITUTED OXOAZETIDINE ANALOGUES AS ROR GAMMA MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2018-10-11 WO disclosed