Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530364 | 0.92 | MAP4K4 (0.47) | HDAC6METPLK1KMT2AADORA3 | |
| SCHEMBL20530355 | 0.90 | RIPK1 (0.43) | HDAC6METMKNK2MAPTKDM4E | |
| SCHEMBL20530352 | 0.88 | HDAC6 (0.41) | HDAC6MKNK2MAPTKDM4EALDH1A1 | |
| SCHEMBL20530354 | 0.88 | AR (0.39) | HDAC6METMKNK2MAPTKDM4E | |
| SCHEMBL20530297 | 0.87 | MKNK1 (0.46) | MKNK2KDM4EMKNK1TP53MAP4K4 | |
| SCHEMBL20530349 | 0.86 | MET (0.48) | METADORA2AADORA1 | |
| SCHEMBL20530335 | 0.86 | MET (0.47) | METKMT2AADORA2AADORA1SLC22A12 | |
| SCHEMBL22729929 | 0.86 | HDAC6 (0.39) | HDAC6MAPTKDM4EALDH1A1POLB | |
| SCHEMBL20530324 | 0.86 | L3MBTL1 (0.52) | MKNK2MAPTKDM4EALDH1A1MKNK1 | |
| SCHEMBL1328370 | 0.83 | MET (0.54) | METPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |