Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530312 | 0.90 | MET (0.39) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL20530302 | 0.87 | MET (0.51) | METKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL20530338 | 0.85 | MET (0.42) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL20530354 | 0.85 | AR (0.39) | METSLC22A12KDM4EALDH1A1MAPT | |
| SCHEMBL2572670 | 0.84 | MET (0.56) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL1330173 | 0.83 | MET (0.61) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL20530341 | 0.82 | HDAC6 (0.43) | METSLC22A12KDM4EALDH1A1TP53 | |
| SCHEMBL20530352 | 0.82 | HDAC6 (0.41) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL20530289 | 0.81 | MET (0.43) | MET | |
| SCHEMBL15284281 | 0.81 | ALDH1A1 (0.43) | METALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |