Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530337 | 0.93 | MET (0.42) | METPARP1 | |
| SCHEMBL20530344 | 0.88 | GPR119 (0.38) | METMEN1KMT2ASUCNR1GRIN2B | |
| SCHEMBL22729910 | 0.87 | MEN1 (0.36) | METMEN1KMT2ASUCNR1GRIN2B | |
| SCHEMBL20530328 | 0.86 | MKNK2 (0.39) | METMEN1KMT2AMKNK1MKNK2 | |
| SCHEMBL1331354 | 0.85 | MET (0.44) | METCASP1MKNK1MKNK2GRIN2B | |
| SCHEMBL1329968 | 0.84 | MET (0.48) | MET | |
| Hydrochloric Acid SCHEMBL1330006 | 0.84 | MET (0.47) | MET | |
| SCHEMBL1330778 | 0.82 | MET (0.56) | MET | |
| SCHEMBL20530371 | 0.81 | MET (0.43) | METPARP1 | |
| SCHEMBL20530291 | 0.81 | PARP1 (0.38) | METMKNK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |