Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 8/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530371 | 0.89 | MET (0.43) | ADORA2AADORA1PARP1METSLC22A12 | |
| SCHEMBL20530360 | 0.87 | SLC22A12 (0.40) | ADORA2AADORA1PARP1METGPR52 | |
| SCHEMBL20530291 | 0.87 | PARP1 (0.38) | ADORA2AADORA1PARP1METSLC22A12 | |
| SCHEMBL20530328 | 0.87 | MKNK2 (0.39) | ADORA2AADORA1PARP1METSLC22A12 | |
| SCHEMBL22729928 | 0.87 | ADORA2A (0.37) | ADORA2AADORA1METDGAT2 | |
| SCHEMBL1328827 | 0.86 | MET (0.52) | MET | |
| SCHEMBL20530305 | 0.86 | PARP1 (0.39) | ADORA2AADORA1PARP1METSLC22A12 | |
| SCHEMBL20530285 | 0.84 | PDE4A (0.39) | ADORA2AADORA1PARP1METSLC22A12 | |
| SCHEMBL20530354 | 0.83 | AR (0.39) | ADORA2AADORA1PARP1METSLC22A12 | |
| SCHEMBL14797795 | 0.82 | MET (0.49) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |