Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530696 | 1.00 | MEN1 (0.41) | MEN1KMT2AALDH1A1LMNAMCOLN3 | |
| SCHEMBL20530717 | 0.82 | GRIN2B (0.39) | ALDH1A1LMNAALOX15HTTTSHR | |
| SCHEMBL20530716 | 0.81 | LMNA (0.39) | ALDH1A1LMNAMCOLN3ALOX15HTT | |
| SCHEMBL20530692 | 0.80 | HSD17B10 (0.36) | ALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL13926355 | 0.79 | KDM4E (0.33) | ALDH1A1LMNAALOX15HTTTSHR | |
| SCHEMBL16726852 | 0.78 | CCR1 (0.42) | ALDH1A1LMNAHTTTSHRKDM4E | |
| SCHEMBL20530688 | 0.78 | KDM4E (0.55) | MEN1KMT2AALDH1A1LMNAALOX15 | |
| SCHEMBL16713122 | 0.78 | KDM4E (0.55) | MEN1KMT2AALDH1A1LMNAALOX15 | |
| SCHEMBL10044970 | 0.76 | LMNA (0.42) | ALDH1A1LMNAALOX15HTTTSHR | |
| SCHEMBL12011964 | 0.74 | SLC40A1 (0.45) | ALDH1A1LMNAALOX15HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | claimed |
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | disclosed |