Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530689 | 0.81 | MEN1 (0.41) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL20530696 | 0.81 | MEN1 (0.41) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL20530728 | 0.75 | CYP1A2 (0.46) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL10044970 | 0.72 | LMNA (0.42) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL20530714 | 0.72 | SMN1; SMN2 (0.48) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL12011964 | 0.70 | SLC40A1 (0.45) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL10311138 | 0.69 | ALDH1A1 (0.45) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL10413672 | 0.69 | CYP1A2 (0.44) | KDM4EMAPTCYP1A2SIGMAR1 | |
| SCHEMBL20530717 | 0.69 | GRIN2B (0.39) | LMNAKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL13926355 | 0.68 | KDM4E (0.33) | LMNAKDM4EMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | claimed |
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | disclosed |