Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530713 | 1.00 | LMNA (0.41) | LMNAMAPTNPSR1GAAITGB3 | |
| SCHEMBL20530728 | 0.73 | CYP1A2 (0.46) | LMNAMAPTGAASMN1; SMN2EGLN1 | |
| SCHEMBL24064896 | 0.71 | LMNA (0.57) | LMNAMAPTNPSR1GAASMN1; SMN2 | |
| SCHEMBL10311138 | 0.70 | ALDH1A1 (0.45) | LMNAMAPTSMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL6006397 | 0.70 | LMNA (0.62) | LMNAMAPTNPSR1GAASMN1; SMN2 | |
| SCHEMBL10044970 | 0.68 | LMNA (0.42) | LMNAMAPTGAASMN1; SMN2ALOX15 | |
| SCHEMBL10311139 | 0.66 | KDM4E (0.39) | LMNAMAPTGAASMN1; SMN2ALOX15 | |
| SCHEMBL20530691 | 0.65 | SMN1; SMN2 (0.40) | MAPTGAASMN1; SMN2ALDH1A1EGLN1 | |
| SCHEMBL20530696 | 0.65 | MEN1 (0.41) | LMNAMAPTSMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL20530689 | 0.65 | MEN1 (0.41) | LMNAMAPTSMN1; SMN2ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | claimed |
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | disclosed |