Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530703 | 0.82 | CYP1A2 (0.43) | CYP1A2SMN1; SMN2KDM4ELMNAGAA | |
| SCHEMBL20530724 | 0.80 | HTR2A (0.46) | LMNAHTTHTR1ADRD2HTR2A | |
| SCHEMBL20530691 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EGAAMAPTEGLN1 | |
| SCHEMBL20530716 | 0.75 | LMNA (0.39) | CYP1A2SMN1; SMN2KDM4ELMNAGAA | |
| SCHEMBL20530714 | 0.75 | SMN1; SMN2 (0.48) | CYP1A2SMN1; SMN2KDM4ELMNAGAA | |
| SCHEMBL20530712 | 0.73 | LMNA (0.41) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL20530713 | 0.73 | LMNA (0.41) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL10044970 | 0.73 | LMNA (0.42) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL10311138 | 0.73 | ALDH1A1 (0.45) | CYP1A2SMN1; SMN2KDM4ELMNAMAPT | |
| SCHEMBL10311139 | 0.70 | KDM4E (0.39) | SMN1; SMN2KDM4ELMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | claimed |
| EP-3388419-A1 | GLI1 INHIBITORS AND USES THEREOF | Leadiant Biosciences SA (CH) | 2018-10-17 | — | — | EP | disclosed |