Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20533479 | 1.00 | KIF11 (0.40) | KIF11CAMK2ADPP8DPP9DPP7 | |
| SCHEMBL21902866 | 0.81 | NR1H2 (0.48) | KDM1ANAMPTABHD6 | |
| SCHEMBL16794188 | 0.81 | NR1H2 (0.48) | KDM1ANAMPTABHD6 | |
| SCHEMBL25489705 | 0.76 | KDM1A (0.34) | KIF11DPP8DPP9DPP7KDM1A | |
| SCHEMBL29104009 | 0.75 | KIF11 (0.44) | KIF11CAMK2ADPP8DPP9DPP7 | |
| SCHEMBL29238643 | 0.74 | KIF11 (0.49) | KIF11CAMK2ADPP8DPP9DPP7 | |
| SCHEMBL19557904 | 0.73 | KDM1A (0.37) | KIF11KDM1A | |
| SCHEMBL31598007 | 0.73 | ABHD6 (0.59) | DPP8DPP9DPP7ABHD6SMN1; SMN2 | |
| SCHEMBL587507 | 0.73 | ABHD6 (0.59) | DPP8DPP9DPP7ABHD6SMN1; SMN2 | |
| SCHEMBL3808915 | 0.73 | ABHD6 (0.59) | DPP8DPP9DPP7ABHD6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609886-B1 | BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC (US) | 2024-02-07 | — | — | EP | disclosed |
| US-11858926-B2 | Inhibiting agents for bruton's tyrosine kinase | BIOGEN MA INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-11820760-B2 | Crystalline polymorphs of Bruton's tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2023-11-21 | — | — | US | disclosed |
| EP-4249071-A2 | BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3793994-B1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC (US) | 2023-08-23 | — | — | EP | disclosed |
| US-20230147490-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. | 2023-05-11 | — | — | US | disclosed |
| US-11427577-B2 | Inhibiting agents for Bruton's tyrosine kinase | BIOGEN MA INC. (US) | 2022-08-30 | — | — | US | disclosed |
| US-20210387972-A1 | CRYSTALLINE POLYMORPHS OF BRUTON'S TYROSINE KINASE INHIBITORS | BIOGEN MA INC. (US) | 2021-12-16 | — | — | US | disclosed |
| US-20210340135-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. | 2021-11-04 | — | — | US | disclosed |
| US-10961237-B2 | Inhibiting agents for Bruton's tyrosine kinase | BIOGEN MA INC. (US) | 2021-03-30 | — | — | US | disclosed |
| WO-2020232330-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2020-11-19 | — | — | WO | disclosed |
| US-20200239459-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. | 2020-07-30 | — | — | US | disclosed |
| WO-2020081514-A9 | CRYSTALLINE POLYMORPHS OF BRUTON'S TYROSINE KINASE INHIBITORS | BIOGEN MA INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2020081514-A1 | CRYSTALLINE POLYMORPHS OF BRUTON'S TYROSINE KINASE INHIBITORS | BIOGEN MA INC. (US) | 2020-04-23 | — | — | WO | disclosed |
| EP-3609886-A1 | BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| US-10227341-B2 | Inhibiting agents for bruton's tyrosine kinase | BIOGEN MA INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-10189829-B2 | Inhibiting agents for Bruton's tyrosine kinase | BIOGEN MA INC. (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180362522-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. | 2018-12-20 | — | — | US | disclosed |
| WO-2018191577-A1 | BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2018-10-18 | — | — | WO | disclosed |
| US-20180297992-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. | 2018-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227341-B2 | Inhibiting agents for bruton's tyrosine kinase | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-10961237-B2 | Inhibiting agents for Bruton's tyrosine kinase | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-20210340135-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-20210387972-A1 | CRYSTALLINE POLYMORPHS OF BRUTON'S TYROSINE KINASE INHIBITORS | ABL1, PRKDC, ABL2 | KIF11 3083/4885CAMK2A 193/4885DPP8 2917/4885 |
| US-20180362522-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-11820760-B2 | Crystalline polymorphs of Bruton's tyrosine kinase inhibitors | ABL1, PRKDC, ABL2 | KIF11 3083/4885CAMK2A 193/4885DPP8 2917/4885 |
| US-20200239459-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-11427577-B2 | Inhibiting agents for Bruton's tyrosine kinase | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-20180297992-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-10189829-B2 | Inhibiting agents for Bruton's tyrosine kinase | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-11858926-B2 | Inhibiting agents for bruton's tyrosine kinase | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
| US-20230147490-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | ABL1, BTK, LYN | KIF11 2737/4885CAMK2A 340/4885DPP8 3513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.