Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PARK7 | Q99497 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 4/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534453 | 0.87 | PARK7 (0.36) | CA1CA2PARK7CASP3TTR | |
| SCHEMBL28587504 | 0.82 | CA1 (0.43) | CA1CA2CASP3TTRCES1 | |
| SCHEMBL28581855 | 0.81 | CA2 (0.44) | CA1CA2CASP3GABRA1GABRG2 | |
| SCHEMBL28588483 | 0.81 | CASP3 (0.63) | CASP3TTRCES1CASP1CASP4 | |
| SCHEMBL28584419 | 0.81 | PIM1 (0.45) | CA1CA2CASP3GABRA1GABRG2 | |
| SCHEMBL28577754 | 0.78 | PARK7 (0.42) | CA1CA2PARK7CASP3TTR | |
| SCHEMBL30704879 | 0.78 | CASP3 (0.62) | CA1CA2PARK7CASP3TTR | |
| SCHEMBL16237987 | 0.78 | CASP3 (0.62) | CA1CA2PARK7CASP3TTR | |
| SCHEMBL28916685 | 0.77 | CHRM5 (0.46) | CES1CHRM5 | |
| SCHEMBL11265954 | 0.76 | TTR (0.58) | CASP3TTRCES1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111961060-B | Preparation method of spiroheterocyclic 2, 3-dihydrobenzofuran compound with optical activity | 遵义医科大学 | 2021-07-06 | — | — | CN | disclosed |
| US-20210130346-A1 | Bromodomain Inhibitors | ABBVIE INC. (US) | 2021-05-06 | — | — | US | disclosed |
| CN-111961060-A | Preparation method of spiroheterocyclic 2, 3-dihydrobenzofuran compound with optical activity | 遵义医科大学 | 2020-11-20 | — | — | CN | disclosed |
| EP-3609896-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018188047-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130346-A1 | Bromodomain Inhibitors | BRD4, BRD1, BRD3 | CA1 2444/4885CA2 3309/4885PARK7 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.