SCHEMBL20534652

SCHEMBL20534652

CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)N(C(=O)O)c1ccc(C#N)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.38
CHRNB4 P30926 1/20 0.38
CHRNA3 P32297 1/20 0.38
CHRNA4 P43681 1/20 0.38
GPR119 Q8TDV5 2/20 0.37
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
CHRM2 P08172 2/20 0.34
CHRM1 P11229 2/20 0.34
CHRM3 P20309 2/20 0.34
SLC22A12 Q96S37 1/20 0.34
PGR P06401 1/20 0.34
AR P10275 1/20 0.34
EGLN2 Q96KS0 1/20 0.33
ABCB1 P08183 1/20 0.33
MLYCD O95822 1/20 0.33
CTSL P07711 1/20 0.33
CTSB P07858 1/20 0.33
CTSS P25774 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20534746 0.91 CHRNB2 (0.45) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL22529835 0.82 CHRNB2 (0.39) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL6650593 0.80 CHRNB2 (0.42) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL3868314 0.79 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL38651897 0.75 MLYCD (0.50) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL19418096 0.75 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL8813059 0.75 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL6453719 0.75 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL8813051 0.75 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4GPR119
SCHEMBL6424007 0.74 NSD2 (0.43) KMT2AMEN1NPC1CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018188962-A1 SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2018-10-18 WO disclosed