Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534476 | 0.86 | FFAR1 (0.44) | FFAR1FFAR4FOLH1KMT2A | |
| SCHEMBL15155706 | 0.81 | GABRP (0.39) | FFAR1FFAR4KMT2A | |
| SCHEMBL28048592 | 0.81 | GABRP (0.39) | FFAR1FFAR4KMT2A | |
| SCHEMBL18885183 | 0.81 | PSEN1 (0.41) | CES2CES1PSEN1PSEN2APH1B | |
| SCHEMBL27728236 | 0.80 | CPA3 (0.45) | CES2CES1KMT2A | |
| SCHEMBL21632034 | 0.78 | CES2 (0.42) | CES2CES1PSEN1PSEN2APH1B | |
| SCHEMBL21632019 | 0.78 | CES2 (0.42) | CES2CES1PSEN1PSEN2APH1B | |
| SCHEMBL27640849 | 0.76 | TSHR (0.53) | — | |
| SCHEMBL19933740 | 0.75 | THRA (0.39) | FFAR1FFAR4FOLH1 | |
| SCHEMBL24222112 | 0.75 | PSEN1 (0.40) | CES2CES1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609870-A1 | SUBSTITUTED N-ARYLETHYL-2-AMINOQUINOLINE-4-CARBOXAMIDES AND USE THEREOF | Bayer Aktiengesellschaft (DE) | 2020-02-19 | — | — | EP | disclosed |
| CN-110709384-A | Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and their use | 拜耳股份公司 | 2020-01-17 | — | — | CN | disclosed |
| WO-2018189012-A1 | SUBSTITUTED N-ARYLETHYL-2-AMINOQUINOLINE-4-CARBOXAMIDES AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-10-18 | — | — | WO | disclosed |