Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30633564 | 1.00 | LMNA (0.54) | LMNACYP1A2CYP3A4USP2TSHR | |
| SCHEMBL18230177 | 0.84 | HTR7 (0.63) | LMNACYP1A2CYP3A4MAPK1HIF1A | |
| SCHEMBL4484046 | 0.82 | HTR6 (0.69) | LMNACYP1A2CYP3A4USP2MAPK1 | |
| SCHEMBL7110831 | 0.80 | POLB (0.54) | LMNAEPHX2NR1H4KMOHDAC1 | |
| SCHEMBL108137 | 0.80 | LMNA (0.53) | LMNACYP1A2MAPK1KMOHDAC3 | |
| SCHEMBL12865171 | 0.79 | MAPT (0.54) | LMNACYP1A2CYP3A4USP2TSHR | |
| SCHEMBL6992776 | 0.79 | LMNA (0.57) | LMNACYP1A2RECQLPIK3CAPIK3CG | |
| SCHEMBL28189078 | 0.79 | HTR7 (0.50) | LMNACYP1A2CYP3A4USP2MAPK1 | |
| SCHEMBL7799017 | 0.79 | MAPK14 (0.57) | LMNAMAPT | |
| SCHEMBL15649054 | 0.78 | LMNA (0.45) | LMNACYP1A2CYP3A4USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018188785-A1 | COMPOUND, COMPOUND FOR USE IN THE TREATMENT OF A PATHOLOGICAL CONDITION, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR PREPARING SAID COMPOUND | Technische Universität München (DE) | 2018-10-18 | — | — | WO | disclosed |