Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535048 | 0.90 | KDM4E (0.55) | ALDH1A1KDM4EHPGDHSD17B10LRRK2 | |
| SCHEMBL20534980 | 0.86 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL20535653 | 0.85 | KDM4E (0.46) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL20535045 | 0.84 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL20535275 | 0.84 | SCN9A (0.43) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL13699672 | 0.82 | KDM4E (0.50) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL20535056 | 0.81 | ICMT (0.47) | ALDH1A1KDM4EHPGDLRRK2MAPT | |
| SCHEMBL20534832 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL20535047 | 0.80 | SLC9A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL20535434 | 0.77 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |