Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535101 | 0.78 | RAPGEF4 (0.47) | RAPGEF4SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL29065515 | 0.78 | RAPGEF4 (0.47) | RAPGEF4SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL20534773 | 0.75 | RAPGEF4 (0.45) | RAPGEF4SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL28726287 | 0.70 | ALDH1A1 (0.42) | RAPGEF4SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL7034798 | 0.68 | ALDH1A1 (0.44) | RAPGEF4SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL6581959 | 0.66 | SMN1; SMN2 (0.79) | SMN1; SMN2LMNAGAAALDH1A1EPHX2 | |
| SCHEMBL28510674 | 0.66 | HTT (0.38) | RAPGEF4SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL7216575 | 0.66 | CA1 (0.49) | RAPGEF4SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL4396834 | 0.65 | ALDH1A1 (0.47) | RAPGEF4SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL645578 | 0.65 | TP53 (0.39) | SMN1; SMN2LMNAALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609896-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018188047-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2018-10-18 | — | — | WO | disclosed |