Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 3/20 | 0.32 |
| ▸ | PHOSPHO1 | Q8TCT1 | 3/20 | 0.32 |
| ▸ | PMM2 | O15305 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498253 | 0.78 | HSD17B10 (0.46) | TDP1HSD17B10ALDH1A1TSHRHTT | |
| SCHEMBL5270640 | 0.70 | HSD17B10 (0.48) | TP53TDP1HSD17B10ALDH1A1TSHR | |
| SCHEMBL7772481 | 0.69 | TUBB4A (0.42) | TP53TDP1HSD17B10ALDH1A1TSHR | |
| SCHEMBL20535401 | 0.65 | RAPGEF4 (0.44) | ALDH1A1HTTKMT2ALMNAMAPT | |
| SCHEMBL2750548 | 0.65 | HSD17B10 (0.43) | TP53TDP1HSD17B10ALDH1A1TSHR | |
| SCHEMBL11569176 | 0.63 | IDO1 (0.44) | TDP1HSD17B10ALDH1A1TSHRMEN1 | |
| SCHEMBL8973467 | 0.63 | MGLL (0.53) | TP53TDP1ALDH1A1HTTMAPT | |
| SCHEMBL16141626 | 0.62 | HSD17B10 (0.41) | TP53TDP1HSD17B10ALDH1A1TSHR | |
| Styrene SCHEMBL7572896 | 0.62 | ALDH1A1 (0.56) | TP53TDP1ALDH1A1TSHRHTT | |
| SCHEMBL9366859 | 0.62 | TDP1 (0.45) | TP53TDP1ALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119660-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-21 | — | — | US | disclosed |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, GNRHR, FSHR | TP53 1188/4885TDP1 4461/4885HSD17B10 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.