Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534830 | 0.91 | MEN1 (0.49) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20535005 | 0.88 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20535061 | 0.85 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20535270 | 0.84 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20535272 | 0.84 | TP53 (0.49) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20535966 | 0.84 | MAPT (0.55) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20535063 | 0.77 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20534979 | 0.77 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20535157 | 0.73 | ALDH1A1 (0.60) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL20534827 | 0.73 | RAB9A (0.69) | MEN1KMT2AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189679-A1 | ISOINDOLINE DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189679-A1 | ISOINDOLINE DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |