Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535966 | 0.88 | MAPT (0.55) | TP53ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL20535270 | 0.88 | ALDH1A1 (0.48) | TP53ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL20535657 | 0.84 | MEN1 (0.47) | ALDH1A1KDM4EHPGDRECQLMEN1 | |
| SCHEMBL20535005 | 0.83 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDRECQLMEN1 | |
| SCHEMBL20535061 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDRECQLMEN1 | |
| SCHEMBL20534830 | 0.82 | MEN1 (0.49) | TP53ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL20535063 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL20534979 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDCA12CA2 | |
| SCHEMBL20535822 | 0.78 | POLB (0.60) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL20534827 | 0.77 | RAB9A (0.69) | TP53ALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189679-A1 | ISOINDOLINE DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189679-A1 | ISOINDOLINE DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |