Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RPS6KA2 | Q15349 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534979 | 0.87 | ALDH1A1 (0.61) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20535822 | 0.84 | POLB (0.60) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20535049 | 0.83 | MEN1 (0.58) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20535966 | 0.81 | MAPT (0.55) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20535270 | 0.81 | ALDH1A1 (0.48) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20535272 | 0.81 | TP53 (0.49) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20535061 | 0.80 | ALDH1A1 (0.46) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20534830 | 0.79 | MEN1 (0.49) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20535657 | 0.77 | MEN1 (0.47) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL20534827 | 0.76 | RAB9A (0.69) | ALDH1A1RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189679-A1 | ISOINDOLINE DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189679-A1 | ISOINDOLINE DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |