Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534979 | 0.84 | ALDH1A1 (0.61) | POLBMAPTRAB9AMEN1HTT | |
| SCHEMBL20535063 | 0.84 | ALDH1A1 (0.53) | POLBMAPTPTGS1LMNARAB9A | |
| SCHEMBL20535049 | 0.80 | MEN1 (0.58) | POLBMAPTLMNARAB9AMEN1 | |
| SCHEMBL20535270 | 0.80 | ALDH1A1 (0.48) | POLBMAPK14RAB9AMEN1KMT2A | |
| SCHEMBL20535272 | 0.78 | TP53 (0.49) | POLBMAPTLMNARAB9AMEN1 | |
| SCHEMBL20535966 | 0.78 | MAPT (0.55) | POLBMAPTLMNARAB9AMEN1 | |
| SCHEMBL20535061 | 0.77 | ALDH1A1 (0.46) | POLBMAPTLMNARAB9AMEN1 | |
| SCHEMBL20534830 | 0.76 | MEN1 (0.49) | POLBRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL20534827 | 0.76 | RAB9A (0.69) | MAPTLMNARAB9AMEN1HTT | |
| SCHEMBL6840871 | 0.75 | KCNK3 (0.59) | POLBCTDSP1MAPTKCNK3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189679-A1 | ISOINDOLINE DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |