Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20538664 | 0.91 | FFAR2 (0.38) | EGLN1MEN1KMT2A | |
| SCHEMBL2566721 | 0.88 | POLB (0.45) | POLBEGLN1MAPK1ELOVL1RAB9A | |
| SCHEMBL20538520 | 0.88 | KMT2A (0.38) | POLBEGLN1MAPK1KDM4ECYP1A2 | |
| SCHEMBL14809015 | 0.87 | MAPK1 (0.33) | POLBEGLN1MAPK1RAB9AMAPT | |
| SCHEMBL20538380 | 0.81 | EGLN1 (0.36) | EGLN1ELOVL1NPSR1KDM4ECYP1A2 | |
| SCHEMBL14809017 | 0.80 | EGLN1 (0.52) | EGLN1MAPK1KDM4EALDH1A1KCNH2 | |
| SCHEMBL14809230 | 0.80 | EGLN1 (0.52) | EGLN1MAPK1KDM4EALDH1A1KCNH2 | |
| SCHEMBL14809016 | 0.80 | EGLN1 (0.52) | EGLN1MAPK1KDM4EALDH1A1KCNH2 | |
| SCHEMBL14809083 | 0.79 | FFAR2 (0.35) | EGLN1MAPK1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL2561322 | 0.78 | LMNA (0.45) | EGLN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758059-B1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME (US) | 2018-10-24 | — | — | EP | claimed |