SCHEMBL20538664 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	FFAR2	O15552	12/20	0.38

▸	HDAC1	Q13547	3/20	0.34

▸	HDAC3	O15379	2/20	0.34

▸	HDAC8	Q9BY41	2/20	0.34

▸	LMNA	P02545	2/20	0.34

▸	TSHR	P16473	1/20	0.34

▸	HDAC4	P56524	1/20	0.34

▸	HDAC6	Q9UBN7	1/20	0.34

▸	EGLN1	Q9GZT9	2/20	0.34

▸	MEN1	O00255	1/20	0.33

▸	KMT2A	Q03164	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20538532	0.91	POLB (0.36)	EGLN1MEN1KMT2A
SCHEMBL2561322	0.88	LMNA (0.45)	FFAR2HDAC1HDAC3HDAC8LMNA
SCHEMBL14809083	0.88	FFAR2 (0.35)	FFAR2HDAC1HDAC3HDAC8LMNA
SCHEMBL20538520	0.86	KMT2A (0.38)	LMNAEGLN1MEN1KMT2A
SCHEMBL20538380	0.79	EGLN1 (0.36)	FFAR2HDAC1HDAC3HDAC8HDAC4
SCHEMBL2562347	0.79	MAPK1 (0.39)	LMNATSHREGLN1
SCHEMBL14809015	0.79	MAPK1 (0.33)	EGLN1MEN1KMT2A
SCHEMBL2566721	0.78	POLB (0.45)	HDAC1HDAC3LMNAEGLN1
SCHEMBL14809017	0.78	EGLN1 (0.52)	LMNAEGLN1
SCHEMBL14809016	0.78	EGLN1 (0.52)	LMNAEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2758059-B1	SUBSTITUTED PYRIMIDINES	MERCK SHARP & DOHME (US)	2018-10-24	—	—	EP	claimed