Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BID | P55957 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13851431 | 0.93 | ALOX15 (0.36) | POLBMTNR1AMTNR1BALOX15GAA | |
| SCHEMBL24338065 | 0.78 | DUSP3 (0.36) | POLBGAATDP1LMNACYP1A2 | |
| SCHEMBL3226491 | 0.77 | PDE4D (0.42) | GAAL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL2035471 | 0.77 | EGFR (0.48) | POLBALOX15GAAMEN1KMT2A | |
| SCHEMBL29491521 | 0.76 | SMN1; SMN2 (0.37) | POLBGAAL3MBTL1MEN1KMT2A | |
| SCHEMBL29241266 | 0.75 | POLB (0.45) | POLBGAAL3MBTL1TDP1MEN1 | |
| SCHEMBL172150 | 0.73 | MTNR1B (0.63) | MTNR1AMTNR1B | |
| SCHEMBL172474 | 0.73 | HTR2A (0.38) | POLBMTNR1AMTNR1BALOX15L3MBTL1 | |
| SCHEMBL28467069 | 0.71 | PDE4D (0.45) | GAAMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL2961663 | 0.71 | TP53 (0.37) | POLBMTNR1AMTNR1BALOX15GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075643-A1 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |