Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | PRNP | P04156 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | FABP3 | P05413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126198 | 0.87 | ALDH1A1 (0.39) | HTR2AHTR2CTDP1L3MBTL1MEN1 | |
| SCHEMBL124840 | 0.80 | HTR2C (0.39) | HTR2AHTR2CMTNR1AMTNR1BTHRB | |
| SCHEMBL124536 | 0.76 | HTR2C (0.40) | HTR2AHTR2CMTNR1AMTNR1B | |
| SCHEMBL126955 | 0.75 | HTR2A (0.37) | HTR2AHTR2CMTNR1AMTNR1B | |
| SCHEMBL2053937 | 0.73 | POLB (0.37) | MTNR1AMTNR1BPOLBTDP1L3MBTL1 | |
| SCHEMBL172150 | 0.68 | MTNR1B (0.63) | HTR2AMTNR1AMTNR1B | |
| SCHEMBL13851431 | 0.68 | ALOX15 (0.36) | MTNR1AMTNR1BPOLBTDP1L3MBTL1 | |
| SCHEMBL19514014 | 0.66 | FABP4 (0.42) | SLC22A12MEN1KMT2AKDM4EFABP3 | |
| SCHEMBL28437880 | 0.66 | GABRP (0.38) | MTNR1AMTNR1BSLC22A12POLBTDP1 | |
| SCHEMBL21584617 | 0.66 | PTGDR2 (0.37) | SLC22A12MEN1KMT2ASMN1; SMN2PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100895-B1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-03-07 | — | — | EP | disclosed |
| EP-2100895-A1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-09-16 | — | — | EP | disclosed |