Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19231462 | 0.68 | CA2 (0.55) | MAPTKDM4EKMT2ASMN1; SMN2BRD4 | |
| SCHEMBL20710538 | 0.67 | MAPT (0.67) | MAPTKDM4EKMT2ASMN1; SMN2PDE5A | |
| SCHEMBL1670909 | 0.67 | PTGS2 (0.40) | MAPTKDM4EKMT2ASMN1; SMN2RAB9A | |
| SCHEMBL9499453 | 0.67 | SMN1; SMN2 (0.45) | MAPTKDM4EKMT2ASMN1; SMN2CYP2A6 | |
| SCHEMBL1079110 | 0.67 | MAPT (0.45) | MAPTKDM4EKMT2ASMN1; SMN2CYP2A6 | |
| SCHEMBL27947016 | 0.67 | MAPT (0.45) | MAPTKDM4EKMT2ASMN1; SMN2CYP2A6 | |
| SCHEMBL12800445 | 0.66 | PTGS2 (0.42) | MAPTKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL1054750 | 0.65 | KDM4E (0.56) | MAPTKDM4EKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2799244 | 0.64 | MAPT (0.50) | MAPTKMT2ASMN1; SMN2PDE5ATNFRSF1A | |
| SCHEMBL10285843 | 0.64 | MAPT (0.50) | MAPTKDM4EKMT2ASMN1; SMN2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180312496-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312496-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD1, BRD4, BRD2 | MAPT 2619/4885KDM4E 1552/4885KMT2A 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.