Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MFN2 | O95140 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20936232 | 0.81 | L3MBTL1 (0.67) | L3MBTL1KMT2ACYP3A4LMNAMEN1 | |
| SCHEMBL21045483 | 0.78 | MFN2 (0.70) | L3MBTL1KMT2AMFN2CYP3A4LMNA | |
| SCHEMBL21045412 | 0.71 | MFN2 (1.00) | L3MBTL1KMT2AMFN2CYP3A4LMNA | |
| SCHEMBL21082494 | 0.71 | MFN2 (0.71) | L3MBTL1KMT2AMFN2CYP3A4LMNA | |
| SCHEMBL20936330 | 0.71 | L3MBTL1 (0.53) | L3MBTL1KMT2ACYP3A4LMNAMEN1 | |
| SCHEMBL21045408 | 0.70 | MFN2 (0.70) | L3MBTL1KMT2AMFN2CYP3A4LMNA | |
| SCHEMBL21045427 | 0.70 | MFN2 (0.69) | L3MBTL1KMT2AMFN2CYP3A4LMNA | |
| SCHEMBL21045551 | 0.69 | MFN2 (0.68) | L3MBTL1KMT2AMFN2CYP3A4LMNA | |
| SCHEMBL23761143 | 0.62 | MFN2 (0.59) | L3MBTL1KMT2AMFN2MEN1ALDH1A1 | |
| SCHEMBL20712985 | 0.61 | MLYCD (0.67) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| WO-2018200323-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY (US) | 2018-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885KMT2A 4381/4885MFN2 1/4885 |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885KMT2A 4381/4885MFN2 1/4885 |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885KMT2A 4381/4885MFN2 1/4885 |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885KMT2A 4381/4885MFN2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.