Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30434330 | 0.91 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL25716301 | 0.89 | L3MBTL1 (0.55) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL20548011 | 0.87 | ALDH1A1 (0.58) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL20936251 | 0.87 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL25416954 | 0.86 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL21082571 | 0.85 | ALDH1A1 (0.56) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL20936195 | 0.85 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL21045523 | 0.85 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL20936190 | 0.84 | ALDH1A1 (0.58) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL20936236 | 0.84 | HTT (0.52) | L3MBTL1ALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081835-A1 | EXPANDING T-CELL USING MITOFUSIN ACTIVATORS AND USES IN CANCER THERAPIES | EMORY UNIVERSITY (US) | 2023-05-11 | — | — | WO | claimed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | claimed |
| US-12409157-B2 | Mitofusin activators and methods of use thereof | DORN, GERALD W., II, DR. | 2025-09-09 | — | — | US | disclosed |
| US-20250099404-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA IN MOTION, INC. (US) | 2025-03-27 | — | — | US | disclosed |
| US-20240366540-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2024-11-07 | — | — | US | disclosed |
| EP-4444284-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | Albert Einstein College of Medicine (US) | 2024-10-16 | — | — | EP | disclosed |
| US-20240082180-A1 | MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | DORN, GERALD W., II, DR. | 2024-03-14 | — | — | US | disclosed |
| US-11813268-B2 | Mitofusin activators and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-11-14 | — | — | US | disclosed |
| US-11813268-B2 | Mitofusin activators and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-11-14 | — | — | US | disclosed |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200345668-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2020-11-05 | — | — | US | disclosed |
| US-20200345669-A1 | MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2020-11-05 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| WO-2019079243-A1 | MITOFUSIN ACTIVATORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2019-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240082180-A1 | MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, FIS1, TFB2M | L3MBTL1 2509/4885ALDH1A1 3892/4885HPGD 1611/4885 |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885ALDH1A1 4127/4885HPGD 1662/4885 |
| US-20200345668-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, TFB2M, HADHA | L3MBTL1 1683/4885ALDH1A1 3019/4885HPGD 482/4885 |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885ALDH1A1 4127/4885HPGD 1662/4885 |
| US-11813268-B2 | Mitofusin activators and uses thereof | MFN2, TFB2M, PCK2 | L3MBTL1 1742/4885ALDH1A1 3698/4885HPGD 853/4885 |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885ALDH1A1 4127/4885HPGD 1662/4885 |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | L3MBTL1 1995/4885ALDH1A1 4127/4885HPGD 1662/4885 |
| US-20200345669-A1 | MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, FIS1, TFB2M | L3MBTL1 2509/4885ALDH1A1 3892/4885HPGD 1611/4885 |
| US-20250099404-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, TFB2M, HADHA | L3MBTL1 1683/4885ALDH1A1 3019/4885HPGD 482/4885 |
| US-12409157-B2 | Mitofusin activators and methods of use thereof | MFN2, FIS1, TFB2M | L3MBTL1 2509/4885ALDH1A1 3892/4885HPGD 1611/4885 |
| US-20240366540-A1 | MITOFUSIN INHIBITORS AND USES THEREOF | TFAM, MFN2, MAVS | L3MBTL1 2456/4885ALDH1A1 2950/4885HPGD 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.