Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CD99 | P14209 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22577530 | 0.92 | HPGD (0.48) | ADORA2AADORA3PDE2AADORA1ADRA1A | |
| SCHEMBL4858272 | 0.91 | HPGD (0.59) | ADORA2AADORA3HPGDLMNANT5E | |
| SCHEMBL25814044 | 0.87 | HPGD (0.43) | ADORA2AADORA3PDE2AADORA1ADRA1A | |
| SCHEMBL20547587 | 0.86 | MEN1 (0.48) | ADORA2AADORA3ADORA1HPGDLMNA | |
| SCHEMBL20547914 | 0.83 | ADORA2A (0.38) | ADORA2AADORA3PDE2AADORA1ADRA1A | |
| SCHEMBL22577553 | 0.83 | HPGD (0.38) | ADORA2AADORA3PDE2AADORA1ADRA1A | |
| SCHEMBL24258539 | 0.79 | SLC29A1 (0.42) | HPGDLMNANT5EPAX8SLC29A1 | |
| SCHEMBL4528206 | 0.79 | PNP (0.54) | PDE4DPDE3ALMNAHIF1ATP53 | |
| SCHEMBL21385677 | 0.77 | ADORA2A (0.63) | ADORA2AADORA3PDE2AADORA1ADRA1A | |
| SCHEMBL4374446 | 0.77 | ADORA2A (0.63) | ADORA2AADORA3PDE2AADORA1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018198084-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS WITH TRICYCLIC NUCLEOBASES | LUPIN LIMITED (IN) | 2018-11-01 | — | — | WO | disclosed |