Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.52 |
| ▸ | CA12 | O43570 | 6/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PARL | Q9H300 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20767982 | 1.00 | CA2 (0.52) | CA2CA12APEX1PTPN1CA1 | |
| SCHEMBL20550038 | 0.91 | CA2 (0.52) | CA2CA12APEX1PTPN1CA1 | |
| SCHEMBL20549874 | 0.83 | CA2 (0.40) | CA2CA12APEX1PTPN1CA1 | |
| SCHEMBL20549969 | 0.80 | PPARG (0.42) | CA2CA12PTPN1TDP1MMP12 | |
| SCHEMBL20787874 | 0.79 | CA12 (0.38) | CA2CA12APEX1PTPN1TDP1 | |
| SCHEMBL8442031 | 0.78 | TDP1 (0.58) | CA2CA12APEX1CA1CA9 | |
| SCHEMBL10950314 | 0.78 | TDP1 (0.58) | CA2CA12APEX1CA1CA9 | |
| SCHEMBL20787587 | 0.77 | MMP12 (0.43) | CA2CA12PTPN1TDP1MMP12 | |
| SCHEMBL29828944 | 0.76 | LIMK1 (0.51) | MEN1KMT2A | |
| SCHEMBL14296006 | 0.76 | LIMK1 (0.51) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221153-B2 | Dibenzothiophene compounds | SAINT LOUIS UNIVERSITY (US) | 2019-03-05 | — | — | US | disclosed |
| US-20180319765-A1 | DIBENZOTHIOPHENE COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10221153-B2 | Dibenzothiophene compounds | DDT, TST, MPST | CA2 4455/4885CA12 3502/4885APEX1 937/4885 |
| US-20180319765-A1 | DIBENZOTHIOPHENE COMPOUNDS | DDT, TST, MPST | CA2 4455/4885CA12 3502/4885APEX1 937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.