Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.33 |
| ▸ | RAF1 | P04049 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.33 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 5/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769635 | 1.00 | KDR (0.35) | KDRPAK1KIF11RPS6KB1RAF1 | |
| SCHEMBL20550485 | 1.00 | KDR (0.35) | KDRPAK1KIF11RPS6KB1RAF1 | |
| SCHEMBL20550709 | 0.96 | KIF11 (0.37) | KDRKIF11RAF1KDM4EBRAF | |
| SCHEMBL17769662 | 0.96 | KIF11 (0.37) | KDRKIF11RAF1KDM4EBRAF | |
| SCHEMBL17769664 | 0.96 | KIF11 (0.37) | KDRKIF11RAF1KDM4EBRAF | |
| SCHEMBL20550338 | 0.93 | KIF18A (0.35) | PAK1KIF11RPS6KB1RAF1KDM4E | |
| SCHEMBL20550591 | 0.93 | KIF18A (0.35) | PAK1KIF11RPS6KB1RAF1KDM4E | |
| SCHEMBL20550336 | 0.93 | KIF18A (0.35) | PAK1KIF11RPS6KB1RAF1KDM4E | |
| SCHEMBL20550594 | 0.91 | KDM4E (0.34) | RPS6KB1RAF1KDM4EALDH1A1CYP2C9 | |
| SCHEMBL20550501 | 0.91 | KDM4E (0.34) | RPS6KB1RAF1KDM4EALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | KDR 1598/4885PAK1 3632/4885KIF11 2817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.