Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HTR1D | P28221 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | HTR2B | P41595 | 4/20 | 0.51 |
| ▸ | HTR5A | P47898 | 4/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553531 | 0.84 | OPRK1 (0.58) | ADRB2ADRA2ACX3CR1HTR7OPRK1 | |
| SCHEMBL21751222 | 0.81 | OPRM1 (0.54) | ADRB2ADRA2ACX3CR1HTR7HTR1A | |
| SCHEMBL20551988 | 0.80 | ADRB2 (0.56) | ADRB2ADRA2ACX3CR1HTR7OPRK1 | |
| SCHEMBL20551968 | 0.79 | ADRB2 (0.55) | ADRB2ADRA2ACX3CR1HTR7HTR1A | |
| SCHEMBL18010426 | 0.78 | HTR1A (0.66) | HTR7HTR1AHTR1DHTR2CHTR2B | |
| SCHEMBL20551971 | 0.77 | ADRB2 (0.53) | ADRB2ADRA2ACX3CR1HTR7OPRK1 | |
| SCHEMBL21751214 | 0.76 | ADRB2 (0.58) | ADRB2ADRA2ACX3CR1OPRK1TP53 | |
| SCHEMBL29424028 | 0.76 | ADRB2 (0.58) | ADRB2ADRA2ACX3CR1OPRK1TP53 | |
| SCHEMBL18010395 | 0.75 | HTR1A (0.70) | HTR7HTR1AHTR1DHTR2CHTR2B | |
| SCHEMBL18010417 | 0.74 | HTR1A (0.70) | HTR7HTR1AHTR1DHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018204370-A1 | CX3CR1 SMALL MOLECULE ANTAGONISTS, AND METHODS USING SAME | DREXEL UNIVERSITY (US) | 2018-11-08 | — | — | WO | claimed |